By air
Flights from Chicago to Knoxville
Fly from Chicago to Knoxville (TYS) — then arrive and explore.
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Flight details and fares
Chicago to Knoxville at a glance
- Arrival airport
- TYS
- Routing
- 1 stop
- Recent fare from
- £402
- Fare found
- 2026-09-14
£402 is the cheapest recent one-way fare our flight-data partner found for Chicago to Knoxville; live prices move daily by date and demand. Check current Chicago to Knoxville fares and pick your dates:
Are there direct flights from Chicago to Knoxville?
Our latest harvest found the best Chicago to Knoxville fare with 1 stop; a non-stop fare was not returned at that check. Direct routes can appear seasonally, so check the live search above for your dates.
The fare is the cheapest our flight-data partner (Travelpayouts) found for Chicago to Knoxville, found around 2026-09-14: a recent SIGNAL, NOT a live or guaranteed quote, always check current fares before booking. The direct/indirect status reflects the routing found at that check and can vary by season and date. Airport codes from OurAirports. How Head Your Way compiles its data.